Anti-TRP1 Antibody [TYRP1/8313R] (A315759)

Anti-TRP1 Antibody [TYRP1/8313R]

Rabbit monoclonal [TYRP1/8313R] antibody to TRP1.

It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

SK-MEL-23, SK-MEL-19, SK-MEL-30 or SK-MEL-37 cells. Human melanoma.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 200-400) of human TYRP1 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

TYRP1/8313R

IgG

Protein A chromatography.

200 µg/ml

75 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

5,6-dihydroxyindole-2-carboxylic acid oxidase, CAS2, Catalase B, DHICA oxidase, Glycoprotein 75, Melanoma antigen gp75, TRP, TRP-1, Tyrosinase-related protein 1, TYRP, TYRP1, TYRRP