Anti-TRF1 Antibody [BED5] (A279805)

$340

Mouse monoclonal [BED5] antibody to TRF1 for WB, IHC-P, IHC-Fr and ELISA.

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 4-6 business days.
Name
Anti-TRF1 Antibody [BED5]
Description
Mouse monoclonal [BED5] antibody to TRF1.
Specificity
This antibody recognises TTAGGG repeat binding factor 1 (TRF1) a ubiquitously expressed 60kDa protein. Along with tankyrase-1, TIN2, and PINX1, TRF1 binds the double-stranded TTAGGG repeat of telomeres and regulates telomere length. Protection of telomeres-1 (POT1) is a single-stranded telomeric DNA-binding protein which controls the elongation of telomeres by telomerase. TRF1 mediates the loading of POT1 onto single stranded DNA, conveying information about telomere length to the telomere terminus, where telomerase is regulated. If the telomere is long enough, telomerase is inhibited. Additionally in conjunction with POT1 and TTAGGG repeat binding factor 1 (TRF2), TRF1 recruits factors to the telomere, inducing the formation of the protective t-loop. TRF1 along with TRF2, POT1, TIN2, TPP1, and Rap1 form the shelterin complex which distinguishes telomeres from sites of DNA damage. TRF1 is thought to play a role in leukaemia being expressed at significantly higher levels in patients with acute lymphoblastic leukaemia than those with myeloid leukaemia. Mouse anti human TRF1 antibody, clone BED5 has been reported to work in western blotting applications.
Applications
WB, IHC-P, IHC-Fr, ELISA
Dilutions
IHC-P 1: 1:200 - 1:1,000
Reactivity
Human
Immunogen
Recombinant TRF1.
Host
Mouse
Clonality
Monoclonal
Clone ID
BED5
Isotype
IgG1
Conjugate

Unconjugated

Purification
Protein A affinity chromatography of tissue culture supernatant.
Concentration
1 mg/ml
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Mouse anti human TRF1 antibody, clone BED5 recognizes TTAGGG repeat binding factor 1 (TRF1) a ubiquitously expressed 60kDa protein. Along with tankyrase-1, TIN2, and PINX1, TRF1 binds the double-stranded TTAGGG repeat of telomeres and regulates telomere length. Protection of telomeres-1 (POT1) is a single-stranded telomeric DNA-binding protein which controls the elongation of telomeres by telomerase. TRF1 mediates the loading of POT1 onto single stranded DNA, conveying information about telomere length to the telomere terminus, where telomerase is regulated. If the telomere is long enough, telomerase is inhibited. Additionally in conjunction with POT1 and TTAGGG repeat binding factor 1 (TRF2), TRF1 recruits factors to the telomere, inducing the formation of the protective t-loop. TRF1 along with TRF2, POT1, TIN2, TPP1, and Rap1 form the shelterin complex which distinguishes telomeres from sites of DNA damage. TRF1 is thought to play a role in leukaemia being expressed at significantly higher levels in patients with acute lymphoblastic leukaemia than those with myeloid leukaemia (Ohyashiki et al. 2001).Mouse anti human TRF1 antibody, clone BED5 has been reported to work in western blotting applications.
Synonyms
NIMA-interacting protein 2, PIN2, Telomeric protein Pin2/TRF1, Telomeric repeat-binding factor 1, TERF1, TRBF1, TRF, TTAGGG repeat-binding factor 1
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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