Anti-Transferrin Antibody [TF/4794] (A315744)

Anti-Transferrin Antibody [TF/4794]

Mouse monoclonal [TF/4794] antibody to Transferrin.

Iron (Fe) is a tightly metabolically controlled mineral and growth factor present in all living cells. Iron not bound in erythrocyte hemoglobin is transported by transferrin (Tf), the iron transport protein of vertebrate serum. The transferrin protein contains two homologous domains, each of which contain an Fe-binding site. The majority of transferrin is synthesized in the liver and secreted into the blood, but it is also produced in lower amounts in testis and brain as well as in oligodendrocytes, where transferrin is an early marker of oligodendrocyte differentiation. From the blood, transferrin is internalized by erythroblasts and reticulocytes upon binding the transferrin receptor (TfR), also designated CD71, through a system of coated pits and vesicles. After Fe release, transferrin is returned to the extracellular medium, where it can be reused. Defects in the transferrin gene results in atransferrinemia, a rare autosomal recessive disorder characterized by microcytic anemia and iron loading.

ELISA, IHC-P

Human liver or hepatocellular carcinoma.

ELISA: 2-4 µg/ml for coating, IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 311-445) of human TF protein. The exact sequence is proprietary.

Mouse

Monoclonal

TF/4794

kappa

Protein A/G chromatography.

200 µg/ml

79 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Beta-1 metal-binding globulin, Serotransferrin, Siderophilin, TF