This antibody recognises human transferrin, also known as beta-1 metal-binding globulin siderophilin or serotransferrin. Transferrin is 647 amino acid ~79 kDa iron binding transport glycoprotein involved in iron translocation from sites of degradation to those of of storage and utilization.Mutations in the TF gene can lead to the iron overload disorder Atransferrinemia (ATRAF) a disease characterized abnormal transferrin production, iron overload and microcytic hypochromic anemia.
Applications
IF, Immunodiffusion
Dilutions
Immunodiffusion: Neat
Reactivity
Human, Guinea Pig, Mouse, Rabbit, Rat, Cat
Cross Reactivity
This antibody does not cross react with Goat, Chicken, Bovine, Pig, Dog, or Horse
Immunogen
Human holo-transferrin.
Host
Sheep
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Concentration
Lot Specific
Product Form
Liquid
Formulation
Supplied in Glycine Buffered Saline with <0.1% Sodium Azide, 0.1% EACA, 0.01% Benzamidine, and 1 mM EDTA.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Sheep anti Human transferrin antibody recognizes human transferrin, also known as beta-1 metal-binding globulin siderophilin or serotransferrin. Transferrin is 647 amino acid ~79 kDa iron binding transport glycoprotein involved in iron translocation from sites of degradation to those of of storage and utilization.Mutations in the TF gene can lead to the iron overload disorder Atransferrinemia (ATRAF) a disease characterized abnormal transferrin production, iron overload and microcytic hypochromic anemia (Knisely et al. 2004).