Recombinant Anti-Topoisomerase II alpha Antibody [TOP2A/6570R] (A278072)

Anti-Topoisomerase II alpha Antibody [TOP2A/6570R]

Recombinant rabbit monoclonal [TOP2A/6570R] antibody to Topoisomerase II alpha.

The topoisomerase II-α isoform is a 170kDa nuclear protein and plays an important role in DNA synthesis and RNA transcription, as well as chromosomal segregation during mitosis. Topoisomerase II-α is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells, and has been shown to be over-expressed in many human cancers. Decreased expression of Topoisomerase II-α is the predominant mechanism of resistance to several chemotherapeutic agents.

WB, IHC-P

WB: 2-4 µg/ml, IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 1,352-1,493, of human Topoisomerase II alpha. The exact sequence is proprietary.

Rabbit

Monoclonal

TOP2A/6570R

IgG

Protein A/G chromatography.

200 µg/ml

170 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Topoisomerase II alpha Antibody [TOP2A/6570R] - BSA and Azide free (A278660).

DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme, TOP2