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Anti-TLR7 Antibody [4F4] (A279380)

$495

Mouse monoclonal [4F4] antibody to TLR7 for ELISA and WB.

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 5-7 business days.
Name
Anti-TLR7 Antibody [4F4]
Description
Mouse monoclonal [4F4] antibody to TLR7.
Specificity
This antibody recognises human TLR7 (toll-like receptor 7), a 121 kDa type I transmembrane protein belonging to the toll-like receptor (TLR) family. TLR7is predominantly expressed in the spleen, lung and placenta. TLRs are highly conserved proteins which play a key role in activation of innate immunity, through the recognition of distinct molecular patterns expressed by infectious agents. TLR7 recognises and interacts with single-stranded RNA (ssRNA) derived from viruses such as influenza , HIV-1 (human immunodeficiency virus type I) and Sendai, and some siRNAs, resulting in the activation of the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway, and the production of proinflammatory signaling molecules.
Applications
ELISA, WB
Dilutions
WB: 1:1,000 - 1:2,000
Reactivity
Human
Immunogen
Recombinant human TLR7 (amino acids 451-500) purified from E. coli.
Sequence
SVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDL
Host
Mouse
Clonality
Monoclonal
Clone ID
4F4
Isotype
IgG1
Conjugate

Unconjugated

Purification
Protein G affinity chromatography of ascites.
Concentration
1 mg/ml
Molecular Weight
Approximately 121 kDa in Ramos cell lysates.
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 10% Glycerol and 0.02% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Mouse anti Human TLR7 antibody, clone 4F4 recognizes human TLR7 (toll-like receptor 7), a 121 kDa type I transmembrane protein belonging to the toll-like receptor (TLR) family. TLR7is predominantly expressed in the spleen, lung and placenta (Chuang et al. 2000).TLRs are highly conserved proteins which play a key role in activation of innate immunity, through the recognition of distinct molecular patterns expressed by infectious agents. TLR7 recognizes and interacts with single-stranded RNA (ssRNA) derived from viruses such as influenza , HIV-1 (human immunodeficiency virus type I) and Sendai, and some siRNAs, resulting in the activation of the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway, and the production of proinflammatory signaling molecules (Diebold et al. 2004).
Synonyms
Toll-like receptor 7
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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