Anti-TIM 1 Antibody (A283057)

Anti-TIM 1 Antibody

Rabbit polyclonal antibody to TIM 1.

This antibody recognises T cell immunoglobulin mucin-1 (TIM-1), which was first identified as the receptor used by hepatitis A for viral entry, it is also known as the hepatitis A virus cellular receptor- HAVCR , TIM -1 also acts as a receptor for other viruses, including Dengue, Ebola and Marburg. TIM-1 is a key cell surface protein that binds TIM-4, leading to T cell proliferation and T helper type 2 (Th2) cytokine production.Two splice variants for human TIM-1 exist; TIM-1a is predominantly expressed in the liver, whilst TIM-1b is expressed in the kidney. Expression of TIM-1 in the kidney is thought to be upregulated in damaged tissue, and is thought to assist healing.TIM-1 polymorphisms are associated with susceptibility to allergy and asthma.

WB: 1.0 - 2 µg/ml

Human, Rat, Mouse

A peptide corresponding to 16 amino acids near the centre of human TIM-1.

Rabbit

Polyclonal

IgG

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti TIM-1 antibody detects T cell immunoglobulin mucin-1 (TIM-1), which was first identified as the receptor used by hepatitis A for viral entry, it is also known as the hepatitis A virus cellular receptor- HAVCR (Curtiss and Colgan 2007), TIM -1 also acts as a receptor for other viruses, including Dengue, Ebola and Marburg (Kondratowicz et al. 2011). TIM-1 is a key cell surface protein that binds TIM-4, leading to T cell proliferation and T helper type 2 (Th2) cytokine production.Two splice variants for human TIM-1 exist; TIM-1a is predominantly expressed in the liver, whilst TIM-1b is expressed in the kidney. Expression of TIM-1 in the kidney is thought to be upregulated in damaged tissue, and is thought to assist healing.TIM-1 polymorphisms are associated with susceptibility to allergy and asthma (Mcintire et al. 2004).

CD365, HAVcr-1, HAVCR1, Hepatitis A virus cellular receptor 1, Kidney injury molecule 1, KIM-1, KIM1, T-cell immunoglobulin and mucin domain-containing protein 1, T-cell immunoglobulin mucin receptor 1, T-cell membrane protein 1, TIM, TIM-1, TIM1, TIMD-1, TIMD1