Anti-Syndecan-1 Antibody [SDC1/7178] (A315709)

Anti-Syndecan-1 Antibody [SDC1/7178]

Mouse monoclonal [SDC1/7178] antibody to Syndecan-1.

CD138, also designated syndecan-1, is a member of the syndecan family of four transmembrane spanning proteins capable of binding to heparan sulfate and chondroitin sulfate molecules. The syndecans main functions are to control cell growth and differentiation as well as to maintain cell adhesion and cell migration. Under normal conditions CD138 is predominantly expressed on mature plasma cells and early preB-cells, while other haematolymphoid cells are negative. Various types of epithelial cells are also CD138 positive. Squamous epithelial cells show strong membranous and some cytoplasmic staining, except for the mature superficial squamous epithelial cells which are unstained. Mature mesenchymal and neural tissues are not stained. Among haematolymphoid neoplasms, CD138 is expressed in practically all cases of plasma cell malignancies. Among non-haematolymphoid neoplasms the expression of CD138 is found in various types of carcinoma.

Human tonsil or lymph node.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 1-250) of human CD138 protein. The exact sequence is proprietary.

Mouse

Monoclonal

SDC1/7178

kappa

Protein A/G chromatography.

200 µg/ml

85 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

CD138, SDC, SDC1, SYND1