Anti-Synaptophysin Antibody [SP15] (A281776)

Anti-Synaptophysin Antibody [SP15]

Mouse monoclonal [SP15] antibody to Synaptophysin.

This antibody recognises human synaptophysin, also known as Major synaptic vesicle protein p38. Synaptophysin is a 313 amino acid synaptic vesicle associated protein of ~38kDa containing a single marvel domain. Synaptophysin expression is ubiquitous in synaptic vesicle membranes where it is the most abundant protein and is involved in the regulation of endocytosis Loss and atypical expression of synaptophysin is noted in conditions such as Huntindon's disease and Alzheimer's disease. Mutations in the synaptophysin gene have been identified and lead to a condition, Mental retardation, X-linked 96. Mouse anti human synaptophysin antibody, clone SP15 has been used for the detection of synaptophysin by immunofluorescence, immunohistochemistry and western blotting on murine , marmoset , rat , lapine and human tissues.

WB, IHC-P, ELISA

IHC-P 1: 1:25, WB: 1:500

Human, Hamster, Rat, Marmoset

Crude human synaptic immunoprecipitate.

Mouse

Monoclonal

SP15

IgM

Ammonium sulphate precipiation of tissue culture supernatant.

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at 4°C.

Mouse anti Human Synaptophysin antibody, clone SP15 recognizes human synaptophysin, also known as Major synaptic vesicle protein p38. Synaptophysin is a 313 amino acid synaptic vesicle associated protein of ~38kDa containing a single marvel domain. Synaptophysin expression is ubiquitous in synaptic vesicle membranes where it is the most abundant protein and is involved in the regulation of endocytosis (Kwon et al. 2011) Loss and atypical expression of synaptophysin is noted in conditions such as Huntindon's disease (Goto and Hirano 1990) and Alzheimer's disease (Masliah et al. 1989). Mutations in the synaptophysin gene have been identified and lead to a condition, Mental retardation, X-linked 96 (Tarpey et al. 2009).Mouse anti human synaptophysin antibody, clone SP15 has been used for the detection of synaptophysin by immunofluorescence, immunohistochemistry and western blotting on murine (Vitry et al. 2009), marmoset (Ramirez et al. 2001), rat (Barr et al. 2004), lapine (Roher et al. 2000) and human tissues (Beach et al. 1997).

Major synaptic vesicle protein p38, SYP