Recombinant Anti-Survivin Antibody [BIRC5/8987R] - BSA and Azide free (A317086)

Anti-Survivin Antibody [BIRC5/8987R] - BSA and Azide free

Recombinant rabbit monoclonal [BIRC5/8987R] antibody to Survivin.

The baculovirus protein p35 inhibits virally induced apoptosis of invertebrate and mammalian cells and may function to impair the clearing of virally infected cells by the host s immune system. This is accomplished at least in part by its ability to block both TNF- and FAS-mediated apoptosis through the inhibition of the ICE family of serine proteases. Two mammalian homologs of baculovirus p35, referred to as inhibitor of apoptosis protein (IAP) 1 and 2, share an amino terminal baculovirus IAP repeat (BIR) motif and a carboxy terminal RING finger. Although the c-IAPs do not directly associate with the TNF receptor (TNF-R), they efficiently block TNF-mediated apoptosis through their interaction with the downstream TNF-R effectors, TRAF1 and TRAF2. Additional IAP family members include ILP (for IAP-like protein) and survivin. ILP inhibits activated caspase-3, leading to the resistance of FAS-mediated apoptosis. Survivin (also designated TIAP) is expressed during the G2/M phase of the cell cycle and associates with microtubules of the mitotic spindle. Increased caspase-3 activity is detected when a disruption of survivin-microtubule interactions occurs.

Human fetal kidney, liver, lymphoma or adenocarcinoma.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 1-100) of human BIRC5 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

BIRC5/8987R

kappa

Protein A/G chromatography.

1 mg/ml

17 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, Baculoviral IAP repeat-containing protein 5, BIRC5, IAP4