Anti-Superoxide Dismutase 1 Antibody [SOD1/4593] - BSA and Azide free (A317080)

Anti-Superoxide Dismutase 1 Antibody [SOD1/4593] - BSA and Azide free

Mouse monoclonal [SOD1/4593] antibody to Superoxide Dismutase 1.

Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

HeLa or Jurkat cells. Human breast or ovarian carcinoma

IHC: 1-2 µg/ml

Human

Recombinant full-length human SOD1 protein.

Mouse

Monoclonal

SOD1/4593

kappa

Protein A/G chromatography.

1 mg/ml

16 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

hSod1, Superoxide dismutase [Cu-Zn]