Anti-Substance P Antibody [NC1/34] (A281317)

Anti-Substance P Antibody [NC1/34]

Rat monoclonal [NC1/34] antibody to Substance P.

This antibody recognises the COOH terminal region of substance P, an eleven amino acid polypeptide neurotransmitter derived by proteolytic cleavage of protachykinin-1. Substance P binds to and activates the neurokinin-1 receptor. Substance P is a highly conserved neurotransmitter expressed throughout the animal kingdom. It is highly expressed in the spinal cord dorsal horn and dorsal root ganglia, but not in the ventral horn (Ribeiro-da-Silva andT Hökfelt 2000). It is also expressed in non-neuronal cells including microglia and other immune cells.Substance P has a role in several physiologic activities such as pain transmission, the vomiting reflex, salivary secretion and smooth muscle contraction (Hökfelt 2004). Rat anti substance P antibody, clone NC1/34 demonstrates ~5% reactivity with eledoisin a neurotransmitter identified in the octopus Genus Eledone. It does not react with Leu or Met-enkephalin, somatostatin or beta-endorphin in tested applications.

IHC-P, IHC-Fr, IF

IHC-Fr: 1:100 - 1:200, IHC-P: 1:100 - 1:200

Mammals, Pig, Pigeon, Bichir, Rabbit, Human, Bovine, Guinea Pig, Calanus sp., Crustacea, Cancer sp., Panilurus sp., Homarus sp., Mudpuppy, Lamprey, Crayfish, Zebrafish, Bullfrog, Amphibia, Cockroach, Sheep, Cowbird, Rat, Spadefoot toad, Chicken, Chinchilla, Camel, Beaver, Chinchilla

Substance P conjugated to Bovine Serum Albumin.

Rat

Monoclonal

NC1/34

IgG2a

Lot Specific

Tissue Culture Supernatant

Liquid

Supplied in 0.05% Thiomersal.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rat anti substance P antibody, clone NC1/34 recognizes the COOH terminal region of substance P, an eleven amino acid polypeptide neurotransmitter derived by proteolytic cleavage of protachykinin-1. Substance P binds to and activates the neurokinin-1 receptor. Substance P is a highly conserved neurotransmitter expressed throughout the animal kingdom. It is highly expressed in the spinal cord dorsal horn and dorsal root ganglia, but not in the ventral horn (Ribeiro-da-Silva andT Hökfelt 2000). It is also expressed in non-neuronal cells including microglia and other immune cells.Substance P has a role in several physiologic activities such as pain transmission, the vomiting reflex, salivary secretion and smooth muscle contraction (Hökfelt 2004).Rat anti substance P antibody, clone NC1/34 demonstrates ~5% reactivity with eledoisin a neurotransmitter identified in the octopus Genus Eledone. It does not react with Leu or Met-enkephalin, somatostatin or beta-endorphin in tested applications.