Anti-SREBP2 Antibody [SREBP2/1579] (A250053)

Mouse monoclonal [SREBP2/1579] antibody to SREBP2 for ELISA.

Alternative Formats and ConjugatesAlternative Formats

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 4-6 business days.
Name
Anti-SREBP2 Antibody [SREBP2/1579]
Description
Mouse monoclonal [SREBP2/1579] antibody to SREBP2.
Specificity
The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a ten base pair sequence in the 5' flanking region, designated sterol regulatory element 1 (SRE-1). When cellular sterol stores are depleted, the element is activated, the gene is transcribed and the cellular uptake of LDL increases. A set of SREbinding proteins (SREBPs) have been identified, including two basic helixloop-helix-leucine zipper (bHLH-zip) transcription factors, designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way.
Applications
ELISA
Reactivity
Human
Immunogen
Recombinant full-length human SREBF2 protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
SREBP2/1579
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
68 kDa / 125 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-SREBP2 Antibody [SREBP2/1579] - BSA and Azide free (A253233).
Synonyms
BHLHD2, Class D basic helix-loop-helix protein 2, SREBF2, SREBP-2, Sterol regulatory element-binding protein 2, Sterol regulatory element-binding transcription factor 2
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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