Anti-SOX10 Antibody [PCRP-SOX10-1D8] (A250018)

Anti-SOX10 Antibody [PCRP-SOX10-1D8]

Mouse monoclonal [PCRP-SOX10-1D8] antibody to SOX10.

The specificity of this monoclonal antibody to its intended target was validated by HuProt^TM Array, containing more than 19,000 full-length human proteins. Recognizes a protein of ~55kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. Expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Often used melanoma markers, such as anti-HMB45 and anti-MelanA, are poorly expressed in desmoplastic melanomas while SOX10 is moderately-to-strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes mammary glands. SOX-10 expression is also observed in mast cells.

IHC-P: 1-2 µg/ml

Human

This antibody is predicted to cross react with Mouse and Rat.

Recombinant fragment, around amino acids 90-179, of human SOX10 protein. The exact sequence is proprietary.

Mouse

Monoclonal

IgG2b

Protein A/G chromatography.

200 µg/ml

49-58 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-SOX10 Antibody [PCRP-SOX10-1D8] - BSA and Azide free (A253198).