Anti-SOS1 Antibody [SOS-01] (A281774)

Anti-SOS1 Antibody [SOS-01]

Mouse monoclonal [SOS-01] antibody to SOS1.

This antibody recognises SOS1 (son of sevenless homolog 1), a ubiquitously expressed 1333 amino acid ~150 kDa intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases.Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 , and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features.

WB, ELISA, IF

WB: 1 µg/ml

Human, Mouse

Synthetic peptide sequence THPSMHRDGPPLLENAHSS of human SOS1.

THPSMHRDGPPLLENAHSS

Mouse

Monoclonal

SOS-01

IgG1

1 mg/ml

Approximately 150 kDa in K562 and RAJI human cell lysates under reducing conditions.

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human SOS1 antibody, clone SOS-01 recognizes SOS1 (son of sevenless homolog 1), a ubiquitously expressed 1333 amino acid ~150 kDa intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases.Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 (Hart et al. 2002), and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features (Hanna et al. 2009).

Son of sevenless homolog 1, SOS-1