Anti-Soluble TNF Receptor II Antibody - BSA and Azide free (A283741)

Anti-Soluble TNF Receptor II Antibody - BSA and Azide free

Rabbit polyclonal antibody to Soluble TNF Receptor II.

WB, ELISA

ELISA: 0.5 µg/ml - 2.0 µg/ml, WB: 0.1 µg/ml - 0.2 µg/ml

Human

E. coli derived recombinant human soluble CD120bcomprising the cysteine-rich, ligand binding portion of the extracellular domain of the CD120b protein.

Rabbit

Polyclonal

IgG

1 mg/ml after reconstitution.

Lyophilized

Supplied in Phosphate Buffered Saline.

Lyophilized: Store at -20°C. Reconstituted: Store undiluted at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Soluble CD120b is also known as TNF receptor type II, TNFRSF1B and p80 TNF-alpha receptor. CD120b is a member of the TNF receptor superfamily and is a single spanning type I transmembrane receptor. Upon binding of its ligand TNF, the adaptor proteins TRAF-2 and TRAF-2-associated proteins are recruited. This results in the activation of the NF-?B signaling pathway as well as the activation of other signaling kinases. TNF-CD120b signaling promotes cell proliferation and survival. A soluble form of CD120b has been described and is produced as a result of alternative splicing or shedding. The soluble form competes with the membrane bound form for the ligand TNF. The binding of TNF to soluble CD120b effectively inhibits TNF signaling by competing with the membrane bound form.

CD120b, p75, p80 TNF-alpha receptor, TNF-R2, TNF-RII, TNFBR, TNFR-II, TNFR2, Tumor necrosis factor receptor 2, Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor type II