Anti-SMAD4 Antibody [SMAD4/2524] - BSA and Azide free (A252453)

Mouse monoclonal [SMAD4/2524] antibody to SMAD4 for ELISA.

Alternative Formats and ConjugatesAlternative Formats

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 4-6 business days.
Name
Anti-SMAD4 Antibody [SMAD4/2524] - BSA and Azide free
Description
Mouse monoclonal [SMAD4/2524] antibody to SMAD4.
Specificity
Signaling from the ligand-activated membrane receptor serine/threonine kinases to nuclear targets is mediated by a set of evolutionarily conserved proteins known as DPC4. Upon ligand binding, the receptors of the TGF- family phosphorylate SMAD proteins (SMAD1 and SMAD2). These proteins then move into the nucleus, where they activate transcription. To carry out this function, the receptor activated SMAD1 and 2 require association with the product of deleted in pancreatic carcinoma, locus 4 (DPC4), also known as SMAD4. SMAD4/DPC4 is also implicated as a tumor suppressor, since it is inactivated in more than half of pancreatic carcinomas and to a lesser extent in a variety of other cancers. SMAD4 is absent in approximately 80% of pancreatic adenocarcinoma, but rarely in endometrial, colorectal, ovarian, lung, breast adenocarcinomas, and malignant melanom. SMAD4 is an important marker for confirming a diagnosis of pancreatic adenocarcinoma. Patients with pancreatic adenocarcinomas with SMAD4 protein expression had significantly longer survival than SMAD4 negative patients.
Applications
ELISA
Dilutions
ELISA: 1-5 µg/ml
Reactivity
Human
Immunogen
Recombinant full-length human STAT6 protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
SMAD4/2524
Isotype
IgG2a
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
61 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-SMAD4 Antibody [SMAD4/2524] (A249273).
Synonyms
Deletion target in pancreatic carcinoma 4, DPC4, hSMAD4, MAD homolog 4, MADH4, Mothers against decapentaplegic homolog 4, Mothers against DPP homolog 4, SMAD 4, SMAD family member 4
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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