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Recombinant Anti-Smad4 Antibody [rSMAD4/6310] - BSA and Azide free (A317037)

$790

Recombinant mouse monoclonal [rSMAD4/6310] antibody to Smad4 for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 5-8 business days.
Name
Anti-Smad4 Antibody [rSMAD4/6310] - BSA and Azide free
Description
Recombinant mouse monoclonal [rSMAD4/6310] antibody to Smad4.
Specificity
Signaling from the ligand-activated membrane receptor serine/threonine kinases to nuclear targets is mediated by a set of evolutionarily conserved proteins known as DPC4.Upon ligand binding, the receptors of the TGF- family phosphorylate SMAD proteins (SMAD1 and SMAD2). These proteins then move into the nucleus, where they activate transcription. To carry out this function, the receptor activated SMAD1 and 2 require association with the product of deleted in pancreatic carcinoma, locus 4 (DPC4), also known as SMAD4. SMAD4/DPC4 is also implicated as a tumor suppressor, since it is inactivated in more than half of pancreatic carcinomas and to a lesser extent in a variety of other cancers. The lack of SMAD4 expression is present in approximately 80% of cases of pancreatic adenocarcinoma, but rarely in endometrial (0%), colorectal (0%), ovarian (3%), lung (0%), breast (2%) adenocarcinomas, and malignant melanoma (4%). SMAD4is an important marker for confirming a diagnosis of pancreatic adenocarcinoma.
Applications
IHC-P
Positive Control
Human pancreatic adenocarcinoma.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human, Mouse,, Rat
Immunogen
Amino acids 1-552 representing full-length human SMAD4.
Host
Mouse
Clonality
Monoclonal
Clone ID
rSMAD4/6310
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
61 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
Deletion target in pancreatic carcinoma 4, DPC4, hSMAD4, MAD homolog 4, MADH4, Mothers against decapentaplegic homolog 4, Mothers against DPP homolog 4, SMAD 4, SMAD family member 4
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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