Reconstitute with 100µl of sterile double-distilled water to bring antibody to 1mg/ml concentration. Gently shake to solubilize completely. Do not vortex!
Formulation
Lyophilized from 25mM Histadine, pH 6.2, with 8% Sucrose and 0.01% Tween80.
Storage
Shipped at 4°C. Lyophilized: Store at -20°C to -80°C. Reconstituted: Aliquot and store at -80°C. Product is stable for one year. Avoid freeze/thaw cycles.
SDS-PAGE analysis of Selicrelumab Biosimilar - Anti-CD40 Antibody - Low endotoxin, Azide free (A323725) under reducing (R) conditions confirms that the purity of this antibody is greater than 95%.
SEC-HPLC analysis of Selicrelumab Biosimilar - Anti-CD40 Antibody - Low endotoxin, Azide free (A323725) confirms that the purity of this antibody is greater than 95%.
Compared with the negative control group, Selicrelumab Biosimilar - Anti-CD40 Antibody - Low endotoxin, Azide free (A323725) had a significant increase in visceral ratio at a dose of 20 MPk and no significant difference at a dose of 1 mpk, indicating that the toxicity of Selicrelumab Biosimilar to the spleen was significantly dose-dependent.
Compared with the negative control group, Selicrelumab Biosimilar - Anti-CD40 Antibody - Low endotoxin, Azide free (A323725) had a significant increase in serum ALT content at a dose of 20 mpk, and a trend of increase in serum ALT at a dose of 1 mpk, but there was no statistical difference. AST indexes were all elevated and dose-dependent, but there was no statistical difference.
Compared with the negative control group, Selicrelumab Biosimilar - Anti-CD40 Antibody - Low endotoxin, Azide free (A323725) had a significant increase in serum ALT content at a dose of 20 mpk, and a trend of increase in serum ALT at a dose of 1 mpk, but there was no statistical difference. AST indexes were all elevated and dose-dependent, but there was no statistical difference.
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