Anti-SDHB Antibody [SDHB/2126] (A277790)

Anti-SDHB Antibody [SDHB/2126]

Mouse monoclonal [SDHB/2126] antibody to SDHB.

Succinate dehydrogenase (SDH) is Complex II in the mitochondria, vital for mitochondrial electron transport, as well as Krebs cycle function.Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. The SDH complex functions as a tumor suppressor. Loss of any subunit proteins lead to destabilization of the complex and tumor formation.Antibody to SDHB is helpful in the identification of phaeochromocytomas, paragangliomas and GIST.

WB, IHC-P

WB: 0.5-1 µg/ml, IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 165-273, of human SDHB. The exact sequence is proprietary.

Mouse

Monoclonal

SDHB/2126

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

32 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-SDHB Antibody [SDHB/2126] - BSA and Azide free (A278378).

Ip, Iron-sulfur subunit of complex II, Malate dehydrogenase [quinone] iron-sulfur subunit, SDH, SDH1, Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial