Recombinant Anti-SDHB Antibody [rSDHB/6948] (A315633)

Anti-SDHB Antibody [rSDHB/6948]

Recombinant mouse monoclonal [rSDHB/6948] antibody to SDHB.

Succinate dehydrogenase B (SDHB) is an iron-sulfur subunit of mitochondrial complex II, a key component of the citric acid cycle and the electron transport chain, a respiratory complex that catalyzes the oxidation of succinate in the mitochondrial membrane.Many cancers are generally positive for SDHB, including renal cell carcinomas and gastrointestinal stromal tumors. A subset of RCC and GIST tumors that are associated with SDH mutations, Carney-Stratakis Syndrome or Carney Triad exhibit a loss of SDHB expression.

Jurkat or HepG2 cells. Human kidney or heart tissue.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 180-280) of human SDHB protein. The exact sequence is proprietary.

Mouse

Monoclonal

rSDHB/6948

IgG1

Protein A/G chromatography.

200 µg/ml

32 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Ip, Iron-sulfur subunit of complex II, Malate dehydrogenase [quinone] iron-sulfur subunit, SDH, SDH1, Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial