Anti-SATB2 Antibody [SATB2/7112] (A315614)

Anti-SATB2 Antibody [SATB2/7112]

Mouse monoclonal [SATB2/7112] antibody to SATB2.

SATB2 is a DNA binding protein that specifically binds nuclear matrix attachment regions. It is involved in transcription regulation and chromatin remodeling. SATB2 expression in colorectal carcinomas (CRC) is correlated with good prognosis and in laryngeal squamous cell carcinoma it functions as a tumor suppressor wherein loss of expression is positively correlated with high tumor grade and recurrence. Moreover, SATB2, in combination with CK20, could identify almost all CRC s. Upper gastrointestinal (GI) carcinomas and pancreatic ductal carcinomas are usually negative for SATB2, and ovarian carcinomas, lung adenocarcinomas, and adenocarcinomas from other origin are rarely positive for SATB2. Additionally, SATB2 antibody can identify neuroendocrine neoplasms of colon and rectum because SATB2 is usually negative in neuroendocrine neoplasms of the GI tract, pancreas, and lung. More recently, it has been reported that SATB2 is a sensitive marker for tumors with osteoblastic differentiation.

Human colon or cerebral cortex tissue.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 150-350) of human SATB2 protein. The exact sequence is proprietary.

Mouse

Monoclonal

SATB2/7112

kappa

Protein A/G chromatography.

200 µg/ml

83 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

DNA-binding protein SATB2, KIAA1034, Special AT-rich sequence-binding protein 2