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Anti-Rel B Antibody [17.3] (A278721)

$495

Mouse monoclonal [17.3] antibody to Rel B for WB, IHC-P, IP, IF and ICC.

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 5-7 business days.
Name
Anti-Rel B Antibody [17.3]
Description
Mouse monoclonal [17.3] antibody to Rel B.
Specificity
This antibody recognises the transcription factor RelB, also known as I-Rel. RelB is encoded by the v-rel avian reticuloendotheliosis viral oncogene homolog B gene and is a critical component of the NF-kappa-B pathway.Upon cleavage of the NF-kappa-B p105 and p100 subunits into the NF-kappa-B p50 and p52 subunits, RelB forms RelB-p50 and RelB-p52 heterodimers. These dimers act as activators of transcription by binding to kappaB sites present on DNA. RelB-p50 and RelB-p52 binding induces the expression of genes mediating immune responses, inflammation and apoptosis. Misregulation of the NF-kappa-B pathway has been implicated in a variety of disease states including autoimmunity and cancer. As the NF-kappa-B pathway has been demonstrated to be constitutively active in a large group of tumors, developing NF-kappa-B inhibitors has emerged as a new cancer therapy approach (Chaturverdi et al. 2011 and Baud and Karin et al. 2009).
Applications
WB, IHC-P, IP, IF, ICC
Dilutions
ICC: 1 µg/ml, IF: 1 µg/ml, IHC-P: 1:10 - 1:50, WB: 1 - 2 µg/ml
Reactivity
Human, Rhesus Monkey, Mouse
Immunogen
Recombinant protein derived from C-terminus of human RelB protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
17.3
Isotype
IgG1
Conjugate

Unconjugated

Purification
Protein A affinity chromatography of tissue culture supernatant.
Concentration
500 µg/ml
Molecular Weight
Approximately 63 kDa in THP-1 cell lysate, Daudi cell lysate, and Raji cell lysate
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.1% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Mouse anti-RelB antibody, clone 17.3 recognizes the transcription factor RelB, also known as I-Rel. RelB is encoded by the v-rel avian reticuloendotheliosis viral oncogene homolog B gene and is a critical component of the NF-kappa-B pathway.Upon cleavage of the NF-kappa-B p105 and p100 subunits into the NF-kappa-B p50 and p52 subunits, RelB forms RelB-p50 and RelB-p52 heterodimers. These dimers act as activators of transcription by binding to kappaB sites present on DNA (Oeckinghaus and Ghosh 2009). RelB-p50 and RelB-p52 binding induces the expression of genes mediating immune responses, inflammation and apoptosis (Jing and Lee 2014).Misregulation of the NF-kappa-B pathway has been implicated in a variety of disease states including autoimmunity and cancer. As the NF-kappa-B pathway has been demonstrated to be constitutively active in a large group of tumors, developing NF-kappa-B inhibitors has emerged as a new cancer therapy approach (Chaturverdi et al. 2011 and Baud and Karin et al. 2009).
Synonyms
I-Rel, Transcription factor RelB
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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