PTEN (phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase) contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. It was identified as a tumor suppressor that is mutated in a large number of cancers, including sporadic brain, breast, kidney, and prostate cancers.
Applications
IHC-P
Positive Control
MCF-7 or HeLa cells. Human prostate, breast, liver or renal carcinoma.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant full-length human PTEN protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
PTEN/7344
Isotype
IgG
Light Chains
kappa
Conjugate
Unconjugated
Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
55 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
Inositol polyphosphate 3-phosphatase, MMAC1, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, TEP1
![Immunohistochemistry - Anti-PTEN Antibody [PTEN/2110] - BSA and Azide free (A252815) - Antibodies.com](https://cdn.antibodies.com/image/catalog/252/A252815_1.jpg?profile=product_alternative)