Anti-PD1 Antibody [EH12.2H7] (PE) (A280348)

Anti-PD1 Antibody [EH12.2H7] (PE)

Mouse monoclonal [EH12.2H7] antibody to PD1 (PE).

This antibody recognises CD279, a co-stimulatory molecule also known as programmed cell death-1 (PD-1).CD279 is a ~50-55 kDa membrane protein which is a member of the CD28 family, and functions as a regulator of T cell activation. It has two specific ligands; CD274 (PD-L1) and CD273 (PD-L2), and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance.CD279 is a marker for germinal center-associated T cells (Dorfman et al, 2006) and is inducibly expressed by T cells, B cells, NKT cells and monocytes upon activation.

Flow Cytometry: Neat, Use 10µl of the suggested working dilution to label 1x10⁶ cells in 100µl

Human, Primate

Mouse

Monoclonal

EH12.2H7

IgG1

Size exclusion chromatography of tissue culture supernatant.

Lot Specific

>95% (by SDS-PAGE).

Liquid

Supplied in Phosphate Buffered Saline with 0.2% BSA and <0.1% Sodium Azide.

Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light.

Mouse anti Human CD279 antibody, clone EH12.2H7 detects CD279, a co-stimulatory molecule also known as programmed cell death-1 (PD-1).CD279 is a ~50-55 kDa membrane protein which is a member of the CD28 family, and functions as a regulator of T cell activation (Fife and Pauken, 2011). It has two specific ligands; CD274 (PD-L1) and CD273 (PD-L2), and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance.CD279 is a marker for germinal center-associated T cells (Dorfman et al, 2006) and is inducibly expressed by T cells, B cells, NKT cells and monocytes upon activation.

CD279, PDCD1, Programmed cell death protein 1, Protein PD-1

This product is for research use only. It is not intended for diagnostic or therapeutic use.