Anti-PD-L2 Antibody [PDL2/2676] (A250390)

Mouse monoclonal [PDL2/2676] antibody to PD-L2 for ELISA, Flow Cytometry, IF and WB.

Alternative Formats and ConjugatesAlternative Formats

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 4-6 business days.
Name
Anti-PD-L2 Antibody [PDL2/2676]
Description
Mouse monoclonal [PDL2/2676] antibody to PD-L2.
Specificity
This antibody recognizes a protein of about 31kDa, which is identified as PD-L2 (same as PDCD1LG2). Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. PD-L2 does not bind CD28, cytotoxic T lymphocyte A4 or ICOS (inducible co-stimulator). The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.
Applications
ELISA, Flow Cytometry, IF, WB
Dilutions
Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment, around amino acids 27-220, of human PD-L2 protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
PDL2/2676
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
31 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-PD-L2 Antibody [PDL2/2676] - BSA and Azide free (A253570).
Synonyms
B7-DC, B7DC, Butyrophilin B7-DC, CD273, PD-1 ligand 2, PDCD1 ligand 2, PDCD1L2, PDCD1LG2, PDL2, Programmed cell death 1 ligand 2, Programmed death ligand 2
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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