Anti-PD-L2 Antibody (A283185)

Anti-PD-L2 Antibody

Rabbit polyclonal antibody to PD-L2.

This antibody recognises human CD273, also known as B7-DC and Programmed Death Ligand 2 (PD-L2). CD273 is a single-pass type 1 membrane protein belonging to the immunoglobulin receptor superfamily, and is a ligand for CD279 (PD-1). CD273 is highly expressed in the tissues of the heart, liver, lung, placenta and pancreas. It is expressed in dendritic cells, and its expression can be induced on inflammatory macrophages when activated by interleukin 4 or Th2 cells. CD273 functions to inhibit T-cell proliferation by blocking cell cycle progression and cytokine production, and is particularly important in the maintenance of self tolerance.

WB, IHC-P

IHC-P 1: 2.5 µg/ml, WB: 0.5 - 1 µg/ml

Human, Mouse, Rat

A peptide corresponding to 16 amino acids near the centre of human CD273.

Rabbit

Polyclonal

IgG

Approximately 30 kDa in Raji cell lysate

Liquid

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human CD273 antibodyrecognizes human CD273, also known as B7-DC and Programmed Death Ligand 2 (PD-L2). CD273 is a single-pass type 1 membrane protein belonging to the immunoglobulin receptor superfamily, and is a ligand for CD279 (PD-1). CD273 is highly expressed in the tissues of the heart, liver, lung, placenta and pancreas. It is expressed in dendritic cells, and its expression can be induced on inflammatory macrophages when activated by interleukin 4 or Th2 cells. CD273 functions to inhibit T-cell proliferation by blocking cell cycle progression and cytokine production, and is particularly important in the maintenance of self tolerance.

B7-DC, B7DC, Butyrophilin B7-DC, CD273, PD-1 ligand 2, PDCD1 ligand 2, PDCD1L2, PDCD1LG2, PDL2, Programmed cell death 1 ligand 2, Programmed death ligand 2