Anti-PD-L2 Antibody [24F.10C12] (A279148)

Anti-PD-L2 Antibody [24F.10C12]

Mouse monoclonal [24F.10C12] antibody to PD-L2.

This antibody recognises human CD273, also known as B7-DC and Programmed Death Ligand 2 (PD-L2). CD273 is a ~42 kDa member of the immunoglobulin receptor superfamily, and is a ligand for CD279 (PD-1). CD273 is primarily expressed on dendritic cells, and its expression can be induced on inflammatory macrophages when activated by interleukin 4 or Th2 cells.CD273 functions to inhibit T-cell proliferation by blocking cell cycle progression and cytokine production, and is particularly important in the maintenance of self tolerance.Clone 24F.10C12 is reported to block CD273 activity and enhance T-cell proliferation (Brown et al, 2003)

Flow Cytometry, IHC-Fr, Functional Assays

Human

Human CD273.

Mouse

Monoclonal

24F.10C12

IgG2a

Protein A affinity chromatography of tissue culture supernatant.

>95% (by SDS-PAGE).

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Store undiluted at 4°C. Do not freeze!

Mouse anti Human CD273 antibody, clone 24F.10C12 detects human CD273, also known as B7-DC and Programmed Death Ligand 2 (PD-L2). CD273 is a ~42 kDa member of the immunoglobulin receptor superfamily, and is a ligand for CD279 (PD-1). CD273 is primarily expressed on dendritic cells, and its expression can be induced on inflammatory macrophages when activated by interleukin 4 or Th2 cells.CD273 functions to inhibit T-cell proliferation by blocking cell cycle progression and cytokine production, and is particularly important in the maintenance of self tolerance.Clone 24F.10C12 is reported to block CD273 activity and enhance T-cell proliferation (Brown et al, 2003)

B7-DC, B7DC, Butyrophilin B7-DC, CD273, PD-1 ligand 2, PDCD1 ligand 2, PDCD1L2, PDCD1LG2, PDL2, Programmed cell death 1 ligand 2, Programmed death ligand 2