Anti-PAX6 Antibody [PAX6/7705] (A315475)

Anti-PAX6 Antibody [PAX6/7705]

Mouse monoclonal [PAX6/7705] antibody to PAX6.

Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.

Human pancreas or cerebellum.

IHC: 1-2 µg/ml

Human

Recombinant fragment (N-terminus; aa 1-300) of human PAX6 protein.

Mouse

Monoclonal

IgG

Protein A/G chromatography.

200 µg/ml

47 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

AN2, Aniridia type II protein, Oculorhombin, Paired box protein Pax-6