Anti-NMDAR2B (phospho Tyr1252) Antibody (A283072)

$645

Rabbit polyclonal antibody to NMDAR2B (phospho Tyr1252) for WB.

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 4-6 business days.
Name
Anti-NMDAR2B (phospho Tyr1252) Antibody
Description
Rabbit polyclonal antibody to NMDAR2B (phospho Tyr1252).
Specificity
This antibody recognises NMDA receptor NR2B, also known as glutamate receptor ionotropic, NMDA 2B (GluN2B), glutamate [NMDA] receptor subunit epsilon-2 and N-methyl D-aspartate receptor subtype 2B (NMDAR2B), when phosphorylated at tyrosine 1252.Receptors for NMDA belong to a group of ionotropic glutamate receptors which play a key role in the mediation of glutamate neurotransmission within the mammalian central nervous system (CNS), including involvement in memory and learning processes. Several antagonists and agonists of NMDA receptors (NMDAR) have been identified, including the glutamate analogue Homoquinolinic acid, which displays a higher affinity for NR2B-containing NMDAR. Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage-dependent Mg2+ blockade and high Ca2+ permeability.The involvement of NMDAR in the CNS implicated in neurodegenerative diseases such as Alzheimer's (Popke 2003) and also epilepsy and ischemic neuronal cell death.
Applications
WB
Dilutions
WB: 1:1,000
Reactivity
Rat, Human, Mouse, Dog, Bovine, Chicken, Zebrafish
Immunogen
Phosphopeptide corresponding to smino acid residues surrounding the phosphorylated Tyr1252 of the NR2B subunit of rat NMDA receptor.
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate

Unconjugated

Concentration
Lot Specific
Molecular Weight
Approximately 180 kDa in rat hippocampal cell lysates.
Product Form
Liquid
Formulation
Supplied in 10 mM Hepes, pH 7.5, with 50% Glycerol, 0.01% BSA, and 0.09% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Rabbit anti Rat NMDA receptor NR2B (pTyr1252) antibody recognizes NMDA receptor NR2B, also known as glutamate receptor ionotropic, NMDA 2B (GluN2B), glutamate [NMDA] receptor subunit epsilon-2 and N-methyl D-aspartate receptor subtype 2B (NMDAR2B), when phosphorylated at tyrosine 1252.Receptors for NMDA belong to a group of ionotropic glutamate receptors which play a key role in the mediation of glutamate neurotransmission within the mammalian central nervous system (CNS), including involvement in memory and learning processes. Several antagonists and agonists of NMDA receptors (NMDAR) have been identified, including the glutamate analogue Homoquinolinic acid, which displays a higher affinity for NR2B-containing NMDAR. Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage-dependent Mg2+ blockade and high Ca2+ permeability.The involvement of NMDAR in the CNS implicated in neurodegenerative diseases such as Alzheimer's (Popke 2003) and also epilepsy and ischemic neuronal cell death.
Synonyms
GluN2B, Glutamate receptor ionotropic, NMDA 2B, Glutamate [NMDA] receptor subunit epsilon-2, GRIN2B, hNR3, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3, NR2B, NR3
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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