Anti-Neuropilin 1 Antibody [NRP1/4620] (A315394)

Anti-Neuropilin 1 Antibody [NRP1/4620]

Mouse monoclonal [NRP1/4620] antibody to Neuropilin 1.

Neuropilin is a type I transmembrane receptor that has been implicated in aspects of axon growth and guidance and has been shown to act as a high affinity receptor for class III semaphorins and vascular endothelial growth factor (VEGF). A closely related protein, neuropilin-2, shares a common domain structure and signifcant homology with neuropilin and also acts as a receptor for the class III semaphorins and VEGF. Both neuropilins are involved in regulating many physiological pathways including axonal guidance and angiogenesis, however they exhibit differential expression in the adult vasculature. Neuropilin-2 is polysialylated and expressed on the surface of dendritic cells. It is also expressed by venous and lymphatic endothelium. Neuropilin is expressed predominantly by arterial endothelium.

Human placenta, testis, kidney or lymph node.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 700-900) of human NRP1 protein. The exact sequence is proprietary.

Mouse

Monoclonal

NRP1/4620

kappa

Protein A/G chromatography.

200 µg/ml

130 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

CD304, NRP, NRP1, Vascular endothelial cell growth factor 165 receptor, VEGF165R