Recombinant Anti-N Cadherin Antibody [CDH2/3874R] (A248059)

Anti-N Cadherin Antibody [CDH2/3874R]

Recombinant rabbit monoclonal [CDH2/3874R] antibody to N Cadherin.

This antibody recognizes a protein of ~140kDa, identified as N-Cadherin (NCAD), also known as CD325. NCAD is a member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently deregulated in cancer cells.Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin.

IHC-P: 1-2 µg/ml

Human

Recombinant full-length human CDH2 protein.

Rabbit

Monoclonal

CDH2/3874R

IgG

Protein A/G chromatography.

200 µg/ml

130-140 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-N Cadherin Antibody [CDH2/3874R] - BSA and Azide free (A251242).

Cadherin-2, CD325, CDH2, CDHN, CDw325, NCAD, Neural cadherin