Anti-N-Cadherin Antibody [13A9] (A279008)

Anti-N-Cadherin Antibody [13A9]

Mouse monoclonal [13A9] antibody to N-Cadherin.

This antibody recognises neural cadherin, otherwise known as CD325, a calcium dependent cell-cell adhesion glycoprotein, and member of the cadherin superfamily, which links to the actin cytoskeleton via catenins, and plays a role in cell-matrix adhesion, cell growth and differentiation, and the establishment of left-right asymmetry.N-cadherin is expressed by neurons, endothelial cells, muscle cells, and stem cells, and is one of the primary cadherins recruited to the site of neuronal synapse formation. N-cadherin is directly involved in the differentiation of early hematopoietic progenitors, and is commonly expressed by cancer cells, playing a role in transendothelial migration and metastasis, through the up-regulation of the src kinase pathway, and subsequent failure of the intercellular connection between two adjacent endothelial cells. Mouse anti Human N-cadherin antibody, clone 13A9 does not recognize E-cadherin, M-cadherin or P-cadherin. Mouse anti Human N-cadherin antibody, clone 13A9 is a reliable marker for the differential diagnosis of pleural mesotheliomas and lung adenocarcinomas, when used in conjunction with E-cadherin.

WB, IHC-P, IF, IHC-Fr, IP

WB: 1:100 - 1:1,000

Human, Rat

Recombinant MBP fusion protein containing the entire cytoplasmic domain of human N-cadherin.

Mouse

Monoclonal

13A9

IgG1

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human N-cadherin antibody, clone 13A9 recognizes neural cadherin, otherwise known as CD325, a calcium dependent cell-cell adhesion glycoprotein, and member of the cadherin superfamily, which links to the actin cytoskeleton via catenins, and plays a role in cell-matrix adhesion, cell growth and differentiation, and the establishment of left-right asymmetry.N-cadherin is expressed by neurons, endothelial cells, muscle cells, and stem cells, and is one of the primary cadherins recruited to the site of neuronal synapse formation. N-cadherin is directly involved in the differentiation of early hematopoietic progenitors, and is commonly expressed by cancer cells, playing a role in transendothelial migration and metastasis, through the up-regulation of the src kinase pathway, and subsequent failure of the intercellular connection between two adjacent endothelial cells. Mouse anti Human N-cadherin antibody, clone 13A9 does not recognize E-cadherin, M-cadherin or P-cadherin (Knudsen et al. 1995). Mouse anti Human N-cadherin antibody, clone 13A9 is a reliable marker for the differential diagnosis of pleural mesotheliomas and lung adenocarcinomas, when used in conjunction with E-cadherin (Han et al. 1997).

Cadherin-2, CD325, CDH2, CDHN, CDw325, NCAD, Neural cadherin