Anti-Myelin Protein Zero Antibody [MPZ/7389] (A315351)

Anti-Myelin Protein Zero Antibody [MPZ/7389]

Mouse monoclonal [MPZ/7389] antibody to Myelin Protein Zero.

Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50% of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e.g. G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS.

Peripheral nerve cells.

IHC: 1-2 µg/ml

Human

Recombinant full-length human MPZ protein.

Mouse

Monoclonal

MPZ/7389

kappa

Protein A/G chromatography.

200 µg/ml

28 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

MPP, MPZ, Myelin peripheral protein, Myelin protein P0