Recombinant Anti-MUC1 Antibody [rMUC1/960] (A249397)

Anti-MUC1 Antibody [rMUC1/960]

Recombinant mouse monoclonal [rMUC1/960] antibody to MUC1.

This antibody reacts with MUC1, a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia. The dominant epitope of This antibody involves both amino acids as well as sugar moieties. Neuraminidase treatment destroys the antigen. It is a very good tracer agent in CA15.3 assays. The extracellular domain of MUC1 largely consists of a highly conserved, O-glycosylated 20 amino acids tandem repeat which can occur 30-100 times per molecule depending on the length of the allele involved. In the vast majority of human carcinomas this protein is up-regulated and poorly glycosylated and appears on the cell surface in a non-polarized fashion.

Flow Cytometry, IF, WB, IHC

Flow Cytometry: 0.5-1 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml, IHC: 0.5-1 µg/ml

Human

Recombinant human MUC1 protein.

Mouse

Monoclonal

rMUC1/960

IgG2b

kappa

Protein A/G chromatography.

200 µg/ml

265-400 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MUC1 Antibody [rMUC1/960] - BSA and Azide free (A252577).

Breast carcinoma-associated antigen DF3, CA 15-3, Cancer antigen 15-3, Carcinoma-associated mucin, CD227, Episialin, H23AG, MUC-1, Mucin-1, PUM