Recombinant Anti-MSH6 Antibody [MSH6/8338R] (A315333)

Anti-MSH6 Antibody [MSH6/8338R]

Recombinant rabbit monoclonal [MSH6/8338R] antibody to MSH6.

MSH6 is a mismatch repair protein which is deficient in a high proportion of patients with microsatellite instability (MSI-H). It has been suggested that the deficiencies in DNA mismatch repair protein(s) can be seen in some malignancies such as hereditary nonpolyposis colorectal cancer (HNPCC) and endometrial cancer. MSH6 expressed in all proliferating cells participate in repair of base-base mismatch, that occur during DNA replication. Loss of MSH6 expression leads to an accumulation of DNA replication errors in the proliferating cells, particularly in areas of the genome with short repetitive nucleotide sequences, a phenomenon known as microsatellite instability (MSI). MSH6 always used as panel with MLH1, MSH2, PMS2, and may be useful to aid in identifying the most probable gene responsiblefor the MSI.

Human colon carcinoma or tonsil.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 1-200) of human MSH6 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

MSH6/8338R

kappa

Protein A/G chromatography.

200 µg/ml

153 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

DNA mismatch repair protein Msh6, G/T mismatch-binding protein, GTBP, GTMBP, hMSH6, MutS protein homolog 6, MutS-alpha 160 kDa subunit, p160