Recombinant humanized monoclonal antibody to NKG2A.
Applications
ELISA, FACS, Functional Assay, In Vivo
Reactivity
Human, Rhesus Macaque, Cynomolgus Macaque, Baboon
Host
Humanized
Clonality
Monoclonal
Isotype
IgG4
Light Chains
kappa
Conjugate
Unconjugated
Purification
Protein A affinity chromatography.
Concentration
Reconstitution dependent.
Molecular Weight
This antibody has a predicted MW of 145 kDa.
Purity
> 90% (by SDS-PAGE and SEC-HPLC).
Product Form
Lyophilized
Reconstitution
Reconstitute with 100µl of sterile double-distilled water to bring antibody to 1mg/ml concentration. Gently shake to solubilize completely. Do not vortex!
Formulation
Lyophilized from 25mM Histadine, pH 6.2, with 8% Sucrose and 0.01% Tween80.
Storage
Shipped at 4°C. Lyophilized: Store at -20°C to -80°C. Reconstituted: Aliquot and store at -80°C. Product is stable for one year. Avoid freeze/thaw cycles.
Synonyms
CD159 antigen-like family member A, CD159a, KLRC1, NK cell receptor A, NKG2-A/B-activating NK receptor, NKG2-A/NKG2-B type II integral membrane protein
SDS-PAGE analysis of Monalizumab Biosimilar - Anti-NKG2A Antibody - Low endotoxin, Azide free (A323588) under reducing (R) conditions confirms that the purity of this antibody is greater than 90%.
SEC-HPLC analysis of Monalizumab Biosimilar - Anti-NKG2A Antibody - Low endotoxin, Azide free (A323588) confirms that the purity of this antibody is greater than 95%.
Human NKG2A/CD94 HEK293 cells were stained with Monalizumab Biosimilar - Anti-NKG2A Antibody - Low endotoxin, Azide free (A323588) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC50 = 0.0409 µg/ml.
Monalizumab Biosimilar - Anti-NKG2A Antibody - Low endotoxin, Azide free (A323588) FACS blocking was evaluated using human NKG2A/CD94 HEK293 cells. The IC50 was approximately 0.2162 nM.
Monalizumab Biosimilar - Anti-NKG2A Antibody - Low endotoxin, Azide free (A323588) Luciferase Assay was evaluated using human NKG2A/CD94 HEK293. The EC50 was approximately 0.5236 nM.
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