Anti-MMP2 Antibody [4D3] (A315327)

Anti-MMP2 Antibody [4D3]

Mouse monoclonal [4D3] antibody to MMP2.

It recognizes a protein of 72kDa, which is identified as MMP2. The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-2 (also designated type IV collagenase) cleaves collagen types IV,V, VII and X and gelatin type I. Activation of MMP-2 secretion requires the Ras signaling pathway.

U-138 MG or U-87 MG cells. Human placenta or colon carcinoma.

IHC: 1-2 µg/ml

Human

Recombinant human MMP2 protein fragment (aa557-569).

Mouse

Monoclonal

4D3

Protein A/G chromatography.

200 µg/ml

72 kDa (Pro) / 63 kDa (cleaved)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

72 kDa gelatinase, 72 kDa type IV collagenase, CLG4A, Enamel metalloproteinase, Enamelysin, Gelatinase A, Matrix metalloproteinase-2, Matrix metalloproteinase-20, MMP-2, MMP-20, MMP20, TBE-1