Anti-Melanoma gp100 Antibody [PMEL/2038] - BSA and Azide free (A253154)

Mouse monoclonal [PMEL/2038] antibody to Melanoma gp100 for ELISA, WB and IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 4-6 business days.
Name
Anti-Melanoma gp100 Antibody [PMEL/2038] - BSA and Azide free
Description
Mouse monoclonal [PMEL/2038] antibody to Melanoma gp100.
Specificity
The gp100 molecule is a 100kDa glycosylated protein that is cleaved into a small (26kDa) carboxy-terminal fragment and a larger amino- terminal section (60-64 kDa), which is subsequently cleaved to generate 26kDa and 34-38kDa fragments. Cytotoxic T lymphocytes (CTLs) recognize melanoma-associated antigens, which belong to three main groups. These groups include tumor-associated testis-specific antigens, melanocyte differentiation antigens and mutated or aberrantly expressed antigens, which are routinely used as markers to identify melanomas based on their binding to specific monoclonal antibodies. gp100, also designated ME20-M, ME20-S and PMEL 17, is classified as a melanocyte differentiation antigen and is expressed at low levels in normal cell lines and tissues, but is upregulated in melanocytes. gp100 is a highly glycosylated protein. It is also the product of proteolytic cleavage, which results in a secreted protein.
Applications
ELISA, WB, IHC-P
Dilutions
WB: 2-4 µg/ml, IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment, within amino acids 376-502, of human SILV protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
PMEL/2038
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
26-100 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Melanoma gp100 Antibody [PMEL/2038] (A249974).
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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