General Notes
Mouse anti MDM2 antibody, clone SMP14 recognizes the ~90 kDa MDM2 protein, which forms a complex with p53 leading to p53 inhibition.MDM2 also acts to stimulate cell proliferation via its induction of transcription factors such as E2F1 and DPI.MDM2 is over expressed in a range of human malignancies, including soft tissue sarcomas, breast cancer and bladder cancer.