Anti-LRP1 Antibody [LRP1/6784] - BSA and Azide free (A316644)

Anti-LRP1 Antibody [LRP1/6784] - BSA and Azide free

Mouse monoclonal [LRP1/6784] antibody to LRP1.

Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LEP1 (low density lipoprotein related protein), megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and apoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP1, also designated LRP and -2-Macroglobulin and apoE. LRP1 is cleaved into a membrane subunit and an extracellular subunit, which remain non-covalently associated. Proper folding and trafficking of LRP1 is facilitated by the receptor-associated protein (RAP), a molecular chaperone. The uptake of all known ligands through LRP1 can be blocked by RAP, which induces a conformational change in the receptor that renders it unable to bind ligands. LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimer s disease (AD), as the human LRP gene localizes to a potential AD locus on chromosome 12.

Human liver, brain or lung.

IHC: 1-2 µg/ml

Human

Recombinant fragment of human LRP1 protein. The exact sequence is proprietary.

Mouse

Monoclonal

LRP1/6784

kappa

Protein A/G chromatography.

1 mg/ml

85 kDa / 515 kDa / 600 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

A2MR, Alpha-2-macroglobulin receptor, APOER, Apolipoprotein E receptor, APR, CD91, LRP-1, Prolow-density lipoprotein receptor-related protein 1