Anti-LOX 1 Antibody [DE15-4H4] (A280235)

Anti-LOX 1 Antibody [DE15-4H4]

Mouse monoclonal [DE15-4H4] antibody to LOX 1.

This antibody recognises lectin-like oxidized LDL receptor 1 (LOX-1) also known as oxidized low density lipoprotein receptor 1 and C-type lectin domain family 8 member A. LOX-1 is a 5 kDa transmembrane glycoprotein and is a member of the class E of the scavenger receptors. It is expressed in a variety of cells including macrophages, vascular smooth muscle cells, cardiomyocytes, platelets and fibroblasts. Proteolytic cleavage of LOX-1 results in the soluble form sLOX-1. The ligand Ox-LDL exerts its biological effects through the LOX-1 receptor, with its binding resulting in induction of the MAPK or NF-?B signaling pathways. Downstream of this, these pathways can trigger the induction of the productions of adhesion molecules and pro-inflammatory cytokines (https://pubmed.ncbi.nlm.nih.gov/30819724/).LOX-1 is expressed at low levels under normal physiological conditions, but is upregulated in various pathological conditions including atherosclerosis, diabetes mellitus, hypertension and dyslipidemia. The purified Mouse anti Human LOX-1 antibody, clone DE15-4H4 (MCA6250GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human LOX-1 antibody, clone DE17-4B9 (MCA6251B) as the detection antibody.

ELISA: 1 µg/ml

Human

HEK293 derived recombinant human full length LOX-1 (Ser61-Gln273).

Mouse

Monoclonal

DE15-4H4

IgG2a

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human LOX-1 antibody, clone DE15-4H4, recognizes lectin-like oxidized LDL receptor 1 (LOX-1) also known as oxidized low density lipoprotein receptor 1 and C-type lectin domain family 8 member A. LOX-1 is a 5 kDa transmembrane glycoprotein and is a member of the class E of the scavenger receptors. It is expressed in a variety of cells including macrophages, vascular smooth muscle cells, cardiomyocytes, platelets and fibroblasts (Kattoor et al. 2019). Proteolytic cleavage of LOX-1 results in the soluble form sLOX-1. The ligand Ox-LDL exerts its biological effects through the LOX-1 receptor, with its binding resulting in induction of the MAPK or NF-?B signaling pathways. Downstream of this, these pathways can trigger the induction of the productions of adhesion molecules and pro-inflammatory cytokines (https://pubmed.ncbi.nlm.nih.gov/30819724/). LOX-1 is expressed at low levels under normal physiological conditions, but is upregulated in various pathological conditions including atherosclerosis, diabetes mellitus, hypertension and dyslipidemia (Kattoor et al. 2019). The purified Mouse anti Human LOX-1 antibody, clone DE15-4H4 (MCA6250GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human LOX-1 antibody, clone DE17-4B9 (MCA6251B) as the detection antibody.

C-type lectin domain family 8 member A, CLEC8A, hLOX-1, Lectin-like oxidized LDL receptor 1, Lectin-like oxLDL receptor 1, Lectin-type oxidized LDL receptor 1, LOX-1, LOX1, Ox-LDL receptor 1, Oxidized low-density lipoprotein receptor 1