Anti-Lck (phospho Tyr394) Antibody (A283638)

Anti-Lck (phospho Tyr394) Antibody

Rabbit polyclonal antibody to Lck (phospho Tyr394).

This antibody recognises LCK, also known as tyrosine-protein kinase Lck, leukocyte C-terminal Src kinase, lymphocyte cell-specific protein-tyrosine kinase or p56-LCK, when phosphorylated at tyrosine 394. LCK is a member of the Src family of tyrosine kinases. The T cell antigen receptor (TCR) depends on LCK to initiate signaling.LCK is autophosphorylated at tyrosine 394 in response to TCR engagement. Phosphorylation of LCK at tyrosine 394 leads to phosphorylation of CD3 and the gamma chains of the TCR as part of T cell activation.

WB: 1:500 - 1:2,000

Human, Mouse

Phospho-specific peptide corresponding to residues surrounding Tyr394 of human LCK.

Rabbit

Polyclonal

IgG

Liquid

Supplied in Phosphate Buffered Saline with 0.05% ProClin 300 and 50% Glycerol.

Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti LCK (pTyr394) antibody recognizes LCK, also known as tyrosine-protein kinase Lck, leukocyte C-terminal Src kinase, lymphocyte cell-specific protein-tyrosine kinase or p56-LCK, when phosphorylated at tyrosine 394. LCK is a member of the Src family of tyrosine kinases. The T cell antigen receptor (TCR) depends on LCK to initiate signaling.LCK is autophosphorylated at tyrosine 394 in response to TCR engagement (Wright et al. 1994). Phosphorylation of LCK at tyrosine 394 leads to phosphorylation of CD3 and the gamma chains of the TCR as part of T cell activation.

Leukocyte C-terminal Src kinase, LSK, Lymphocyte cell-specific protein-tyrosine kinase, p56-LCK, Protein YT16, Proto-oncogene Lck, T cell-specific protein-tyrosine kinase, Tyrosine-protein kinase Lck