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Anti-LAMP2 Antibody (A283169)

$485

Rabbit polyclonal antibody to LAMP2 for WB and IHC-Fr.

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 5-7 business days.
Name
Anti-LAMP2 Antibody
Description
Rabbit polyclonal antibody to LAMP2.
Specificity
This antibody recognises CD107b, also known as LAMP-2, a single-pass type I membrane protein belonging to the LAMP family. CD107b is a transmembrane glycoprotein associated with lysosomal membranes and is primarily expressed on mononuclear phagocytes. Expression of CD107b varies between cell populations and the molecular weight of CD107b can vary between 92-120 kDa. recognises a band migrating at ~115 kDa in SDS page. CD107b is involved in a range of cellular processes including leukocyte adhesion , protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome along with inter- and intracellular signal transduction (Eskelinen 2006). CD107b has also been implicated in tumor metastasis.
Applications
WB, IHC-Fr
Dilutions
IHC-Fr: 10 µg/ml, WB: 1.0 - 2 µg/ml
Reactivity
Human, Mouse
Immunogen
A peptide corresponding to 17 amino acids near the C-terminus of human CD107b.
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate

Unconjugated

Concentration
1 mg/ml
Molecular Weight
Approximately 115 kDa in HepG2 cell lysate.
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Rabbit anti Human CD107b antibody recognizes CD107b, also known as LAMP-2, a single-pass type I membrane protein belonging to the LAMP family. CD107b is a transmembrane glycoprotein associated with lysosomal membranes and is primarily expressed on mononuclear phagocytes. Expression of CD107b varies between cell populations and the molecular weight of CD107b can vary between 92-120 kDa. Rabbit anti Human CD107b antibody recognizes a band migrating at ~115 kDa in SDS page. CD107b is involved in a range of cellular processes including leukocyte adhesion (Kannan et al. 1996), protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome along with inter- and intracellular signal transduction (Eskelinen 2006). CD107b has also been implicated in tumor metastasis (Alessandrini et al. 2017).
Synonyms
CD107 antigen-like family member B, CD107b, LAMP-2, LGP-96, Lysosome-associated membrane glycoprotein 2
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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