Anti-LAMP1 Antibody [LAMP1/7456] (A315232)

Anti-LAMP1 Antibody [LAMP1/7456]

Mouse monoclonal [LAMP1/7456] antibody to LAMP1.

Lysosome-associated membrane proteins (LAMP) are glycosylated type I membrane proteins that play a role in the biogenesis of the pigment melanin. LAMP-1 (also designated CD107a) and LAMP-2 (also designated CD107b) are involved in a variety of functions, including cellular adhesion, and are thought to participate in the process of tumor invasion and metastasis. Newly synthesized LAMP-1 and LAMP-2 proteins are sorted at the trans-Golgi network and are transported intracellularly via a pathway that is distinct from the Clathrincoated vesicles used for the mannose-6 phosphate receptor. LAMP-1 is expressed on the surface of Thrombin-activated but not resting platelets, and it is thought to be involved in the adhesive, prothrombic properties of these cells. Both LAMP-1 and LAMP-2 are involved in maintaining lysosome acidity and protecting the lysosomal membranes from autodigestion, and their expression is increased in patients with lysosomal storage disorders.

Human tonsil, placenta, kidney or prostate.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 200-400) of human LAMP1 protein. The exact sequence is proprietary.

Mouse

Monoclonal

LAMP1/7456

kappa

Protein A/G chromatography.

200 µg/ml

120 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

CD107 antigen-like family member A, CD107a, LAMP-1, Lysosome-associated membrane glycoprotein 1