Recombinant Anti-Ki67 Antibody [MKI67/8005R] (A315215)

Anti-Ki67 Antibody [MKI67/8005R]

Recombinant rabbit monoclonal [MKI67/8005R] antibody to Ki67.

Ki-67 antigen is a nuclear, non-histone protein that is present in all stages of the cell cycle except G0. This characteristic makes Ki-67 an excellent marker for proliferating cells and is commonly used as one of the prognostic factors in cancer studies. A correlation has been demonstrated between Ki-67 index and the histo-pathological grade of neoplasms. Assessment of Ki-67 expression in renal and ureter tumors shows a correlation between tumor proliferation and disease progression, thus making it possible to differentiate high-risk patients. Ki-67 expression may also prove to be important for distinguishing between malignant and benign peripheral nerve sheath tumors. Ki-67 labeling index has been shown to be a prognostic marker in a number of neoplasms including grade II astrocytoma, oligodendroglioma, colon carcinoma, and breast carcinoma. In general, Ki-67 is a good marker of proliferating cell populations.

Any actively proliferating cells. Human skin, tonsil or lymph node.

IHC: 1-2 µg/ml

Human

Recombinant fragment corresponding to C-terminus of human Ki67 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

MKI67/8005R

kappa

Protein A/G chromatography.

200 µg/ml

345 kDa / 395 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Antigen identified by monoclonal antibody Ki-67, Antigen KI-67, Antigen Ki67, MKI67, Proliferation marker protein Ki-67