Rabbit polyclonal antibody to IRS1 (phospho Ser312).
Specificity
This antibody recognises insulin receptor substrate 1 (IRS1), when phosphorylated at serine 312. IRS proteins are substrates of the insulin receptor tyrosine kinase and play a key role in insulin signaling.IRS1 is phosphorylated at serine 312 by MAPK8/JNK1 and IKK, inhibiting insulin signaling.
Applications
WB
Dilutions
WB: 1:500 - 1:2,000
Reactivity
Human, Mouse, Rat
Immunogen
Phospho-specific peptide corresponding to residues surrounding Ser312 of human IRS1.
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Concentration
Lot Specific
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 50% Glycerol and 0.02% Sodium Azide.
Storage
Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.
General Notes
Rabbit anti IRS1 (pSer312) antibody recognizes insulin receptor substrate 1 (IRS1), when phosphorylated at serine 312. IRS proteins are substrates of the insulin receptor tyrosine kinase and play a key role in insulin signaling.IRS1 is phosphorylated at serine 312 by MAPK8/JNK1 and IKK, inhibiting insulin signaling (Zhang et al. 2008).
