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Anti-IRF3 Antibody [PCRP-IRF3-3B2] (A277870)

Mouse monoclonal [PCRP-IRF3-3B2] antibody to IRF3 for WB and IF.

Alternative Formats and ConjugatesAlternative Formats

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 5-8 business days.
Name
Anti-IRF3 Antibody [PCRP-IRF3-3B2]
Description
Mouse monoclonal [PCRP-IRF3-3B2] antibody to IRF3.
Specificity
Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-αand β) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-αand interferon-βgenes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3γp48 and IFN consensus sequence-binding protein (ICSBP).
Applications
WB, IF
Dilutions
WB: 2-4 µg/ml, IF: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant full-length human IRF3 protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
PCRP-IRF3-3B2
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
50 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-IRF3 Antibody [PCRP-IRF3-3B2] - BSA and Azide free (A278458).
Synonyms
Interferon regulatory factor 3, IRF-3
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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