Specificity
This antibody recognises an epitope within the N-terminal region of human interleukin-21 receptor (IL-21R), a type I transmembrane protein and member of the type I cytokine receptor family, selectively expressed by lymphoid tissues, which acts as the receptor for IL-21.Interaction between IL-21R and IL-21 results in the activation of several downstream signaling molecules including JAK1 and STAT1 and plays an essential role in the differentiation and proliferation of B cells, T cells and natural killer (NK) cells.