Anti-IL-11 Antibody [D08-4C12] (A280203)

Anti-IL-11 Antibody [D08-4C12]

Mouse monoclonal [D08-4C12] antibody to IL-11.

This antibody recognises interleukin-11 (IL-11), also known as AGIF. IL-11 belongs to the IL-6 family of cytokines, and plays a protective role in acute inflammatory settings. IL-11 has both pro- and anti-inflammatory functions through activation of signaling cascades. IL-11 is largely absent in the body fluids of healthy people, but is upregulated in a series of diseases. IL-11 can be expressed in fibroblasts, and its inhibition has been suggested as a treatment for fibrotic disease , including fibrotic cardiovascular diseases. A role of IL-11 has also been identified in development of inflammation-associated cancers, and its inhibition may be a therapeutic goal. The purified Mouse anti Human interleukin-11 antibody, clone D08-4C12 (MCA6204GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human interleukin-11 antibody, clone C16-4B8 (MCA6205B) as the detection antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human full length interleukin-11 (Pro22-Leu199).

Mouse

Monoclonal

D08-4C12

IgG1

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human interleukin-11 antibody, clone D08-4C12, recognizes interleukin-11 (IL-11), also known as AGIF. IL-11 belongs to the IL-6 family of cytokines, and plays a protective role in acute inflammatory settings (Traber et al. 2019). IL-11 has both pro- and anti-inflammatory functions through activation of signaling cascades (Lokau et al. 2017). IL-11 is largely absent in the body fluids of healthy people, but is upregulated in a series of diseases. IL-11 can be expressed in fibroblasts, and its inhibition has been suggested as a treatment for fibrotic disease (Schafer et al. 2017), including fibrotic cardiovascular diseases (Ye et al. 2019). A role of IL-11 has also been identified in development of inflammation-associated cancers, and its inhibition may be a therapeutic goal (Putoczki et al. 2013). The purified Mouse anti Human interleukin-11 antibody, clone D08-4C12 (MCA6204GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human interleukin-11 antibody, clone C16-4B8 (MCA6205B) as the detection antibody.

Adipogenesis inhibitory factor, AGIF, IL11, Interleukin-11